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Risk Factor Involved in Knee Osteoarthritis (KOA)

NCT05749601 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 85

Last updated 2023-03-03

No results posted yet for this study

Summary

Clinical study regarding the incidence and severity of knee osteoarthritis (KOA) in a certain area from South-Eastern Europe. Aim of the clinical study: to determine the KOA grade through X-Ray studies, to perform nuclear magnetic resonance (NMR) analysis to assess the KOA severity and to determine the level of significant parameters in the synovial liquid extracted from the patients presenting KOA.

Conditions

Interventions

OTHER

Influence of the metabolic syndrome (MetS) parameters on knee osteoarthritis (KOA) severity, the assesment of the reactive oxygen species and reactive nitrogen species in knee synovial fluid

Highlighting the influence of environment of origin on KOA incidence and corelated impact of high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, triglycerides and body mass index (BMI). The analytes from synovial fluid were determined by fluorometric method.

OTHER

The influence of patellofemoral morphology in the radiological severity of knee osteoarthritis

Highlighting the influence of distal femoral torsion angle, patellofemoral congruence angle and sulcus angle, in KOA severity under the influence of sex and age.

OTHER

The influence of ROS from the synovial fluid on the severity of KOA

Highlighting the influence of ROS from the synovial fluid in KOA severity under the influence of some biochemicals blood constants.

Sponsors & Collaborators

  • Iacob Czihac Emergency Military Clinical Hospital

    lead NETWORK

Principal Investigators

  • Nicoleta B Tudorachi, MD · "Ovidius" University of Constanța, Romania

Study Design

Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-01
Primary Completion
2022-06-16
Completion
2022-08-19

Countries

  • Romania

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05749601 on ClinicalTrials.gov