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Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis

NCT02722772 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2016-04-08

No results posted yet for this study

Summary

Primary aim: evaluate efficacy of intra-articular injection of etanercept for moderate and severe knee osteoarthritis.

Second aim: investigate the potentiality of serum cytokines (TNF-α, Interleukin 1-α (IL1-α), IL1-β, matrix metalloproteinases1 (MMP1), MMP13) to predict the response of intra-articular injection of etanercept for moderate and severe knee osteoarthritis.

Conditions

  • Osteoarthritis of Knee

Interventions

DRUG

Etanercept

Intra-articular injection of etanercept of 25mg/w/joint for 5 weeks.

OTHER

Health education, exercise and diet guidance

Health education, exercise and diet guidance in patient; treatment: 5 weeks

Sponsors & Collaborators

  • Shanghai baiying pharmaceutical technology Co., Ltd.

    collaborator UNKNOWN

  • First Affiliated Hospital of Harbin Medical University

    lead OTHER

Principal Investigators

  • Zhiyi Zhang · First Affiliated Hospital of Harbin Medical University

  • Yifang Mei, M.D · First Affiliated Hospital of Harbin Medical University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-02-29
Primary Completion
2017-07-31
Completion
2017-08-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02722772 on ClinicalTrials.gov