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Validating Gulf War Illness Blood Biomarkers

NCT05736146 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-07-24

No results posted yet for this study

Summary

The investigators goals are to identify blood lipids/metabolites that correlate with cognitive decline in the presence of the APOE ε4 allele among veterans with GWI. To determine the effect of dietary, medical and biological factors that influence lipid and metabolites in blood from GW veterans. To identify blood lipid/metabolite profiles that correlate with bioenergetics deficits and glial activation in the brains of GWI. To validate blood biomarker signatures of GWI using APOE genotyping and blood lipids/metabolites that correlate with the CNS dysfunction in GWI.

Conditions

  • Gulf War Syndrome
  • Gulf War Illness

Sponsors & Collaborators

  • Boston University

    collaborator OTHER

  • Palo Alto Veterans Institute for Research

    collaborator OTHER

  • United States Department of Defense

    collaborator FED

  • Roskamp Institute Inc.

    lead OTHER

Principal Investigators

  • Laila Abdullah, Ph.D. · The Roskamp Institute

  • Michael Hoffmann, MD · The Roskamp Institute

  • Kim Sullivan, Ph.D · Boston University

  • Maheen Adamson, Ph.D. · Palo Alto Veterans Institute of Research

Eligibility

Min Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-06-30
Primary Completion
2025-12-01
Completion
2026-03-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05736146 on ClinicalTrials.gov