Effect of Genetic and Epigenetic Factors on the Clinical Response and Toxicity to Doxorubicin Among Egyptian Breast Cancer Patients
NCT05733026 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200
Last updated 2023-02-17
Summary
Recent advances in technologies, such as microarray and high-throughput sequencing, represented a deeper understanding of molecular biology, especially noncoding RNA (ncRNA). It was found that there are only \<2 % of the total genome sequence as protein-coding genes while at least 98 % of the genome are transcribed into ncRNA. In the past, non-protein-coding RNAs were known as "transcription noise," but now it is obvious that ncRNAs play a crucial regulatory role in cell differentiation and organism growth and metabolism.
Conditions
Sponsors & Collaborators
-
Ain Shams University
lead OTHER
Eligibility
- Min Age
- 18 Years
- Max Age
- 80 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-08-01
- Primary Completion
- 2023-01-01
- Completion
- 2023-04-01
Countries
- Egypt
Study Locations
More Related Trials
-
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population
NCT06357689 ·Status: COMPLETED
-
Universal Genetic Testing Versus Guidelines-Directed Testing for Germline Pathogenic Variants Among Non-Western Patients With Breast Cancer
NCT04920656 ·Status: COMPLETED
-
Circulating microRNA 21 Expression Level Before and After Neoadjuvant Systemic Therapy in Breast Carcinoma
NCT05151224 ·Status: UNKNOWN
-
Mutation of BRCA1/2 and Other Potential Genes in Triple-negative Breast Cancer
NCT02670668 ·Status: UNKNOWN ·Phase: NA
-
ScreenIng of Genetic Susceptibility Genes for Breast Cancer Patients in CHinese communiTies
NCT04265937 ·Status: RECRUITING
-
The Role of C1q Tumor Necrosis Factor-related Protein 6 in Breast Cancer
NCT04611308 ·Status: UNKNOWN
-
Role of Cytochrome P450 2D6 (CYP2D6) *4 Polymorphism,in Malignant Breast Diseases
NCT00539422 ·Status: COMPLETED
-
Concordance of the Biology of Primary Breast Carcinoma and the Biology of Recurrence .
NCT07275203 ·Status: NOT_YET_RECRUITING
-
Biomarkers for Breast Cancer Risk in African American Women
NCT01736306 ·Status: COMPLETED
-
Study of Metabolites Markers in Adjuvant Breast Cancer
NCT03367208 ·Status: COMPLETED
-
CD133 Expression in Mammary Invasive Ductal Carcinoma
NCT04873154 ·Status: UNKNOWN
-
Transcripts with Retained H/ACA Box SnoRNA Sequences As Biomarkers for Estrogen Dependence in Lum-B Breast Carcinomas
NCT06805084 ·Status: ACTIVE_NOT_RECRUITING
-
EpCAM and p53 Expressions in Infiltrating Duct Carcinoma of the Breast
NCT05703815 ·Status: UNKNOWN
-
Diagnostic and Prognostic Value of MicroRNA in Breast Cancer Patients
NCT04778202 ·Status: UNKNOWN
-
Prognostic Value of Circulating Tumor DNA Dosing in Patients in Neoadjuvant Breast Neoplasia
NCT05050890 ·Status: UNKNOWN
-
Potential of Circulating Tumor DNA to Assess the Tumor Response to Neoadjuvant Chemotherapy in Breast Cancer Patients
NCT03688035 ·Status: UNKNOWN
-
Differential Expression and Potential Value of c-MYC in Non-Invasive and Invasive Mammary Carcinoma
NCT06357338 ·Status: ENROLLING_BY_INVITATION
-
Transcriptional and Epimetabolic Profile of Breast Carcinoma With Luminal or HER2+ or Locally Advanced Triple-negative Histotype in Patients With/Without Previous Clinical History of Metabolic Syndrome
NCT06261918 ·Status: RECRUITING
-
Circulating MicroRNA as Biomarker of Cardiotoxicity in Breast Cancer
NCT02065908 ·Status: COMPLETED
-
Comparative Expression of ER,PR and HER2/Neu in Initial and Recurrent Breast Cancer.
NCT07056205 ·Status: ENROLLING_BY_INVITATION
-
Effectiveness of Introducing Ultra-High B-Value Diffusion-Weighted Imaging as a Modified Abbreviated Protocol for Breast Cancer Detection
NCT06970288 ·Status: RECRUITING
-
The Effect of Metformin on Breast Cancer Patients
NCT04559308 ·Status: UNKNOWN ·Phase: PHASE2
-
Programmed Death-Ligand1 Expression in Her-2 Positive and Triple Negative Breast Cancer
NCT05169853 ·Status: ACTIVE_NOT_RECRUITING
-
Developing Plasma DNA as a Surrogate for Tumor Biopsy to Identify Tumor Genetic Alterations in Patients With Advanced Breast Cancer
NCT01836640 ·Status: TERMINATED
-
Identifying Genes That Predict Recurrence in Women With Breast Cancer Treated With Chemotherapy
NCT00897299 ·Status: COMPLETED