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Role of Cytochrome P450 2D6 (CYP2D6) *4 Polymorphism,in Malignant Breast Diseases

NCT00539422 · Status: COMPLETED · Type: OBSERVATIONAL

Last updated 2007-10-04

No results posted yet for this study

Summary

The aim of our study is to investigate the potential role of the CYP2D6\*4 polymorphism in breast cancer and furthermore to assess the role of oxidative stress, antioxidant capacity and ferretin in pathogenesis of breast cancer in different CYP2D6\*4 genotypes

Conditions

Interventions

GENETIC

pcr and serum markers for breast cancer

DNA extraction and genotyping of cytochrome P450-2D6\*4 gene using conventional PCR followed by restriction enzyme (Mva1) digestion. Separated plasma was used for measurement of plasma malondialdehyde(MDA)concentration, total plasma antioxidant capacity and plasma ferretin level.

Sponsors & Collaborators

  • Mansoura University

    lead OTHER

Principal Investigators

  • wagih m ghnnam · mansoura faculty of medicine general surgery department

  • Aymen z El Samanoudy · mansoura faculty of medicine biochemistry department

Eligibility

Min Age
33 Years
Max Age
63 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-01-31
Completion
2007-04-30

Countries

  • Egypt

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00539422 on ClinicalTrials.gov