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Correlation Between Myocardial Injury and Intestinal Flora Changes Associated With Oncology Drug Therapy and the Preventive of Probiotics

NCT05730777 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2023-02-16

No results posted yet for this study

Summary

The purpose of this study was to explore the relationship between early myocardial injury caused by tumor drug therapy and intestinal microbial structure changes by echocardiographic two-dimensional speckle tracking technique and intestinal microflora structure detection. The investigators will also explore prevention and treatment through randomized controlled trials to initiate early intervention before clinical symptoms appear.

Conditions

  • Cancer Therapy-related Cardiovascular Toxicity

Interventions

DRUG

Bifidobacterium Bifidum Oral Capsule

Bifidobacterium Bifidum Oral Capsule for 6 months in addition to conventional treatment

DRUG

Cisplatin

Patients in the control group will receive conventional antitumor treatment only.

DRUG

Carboplatin

Patients in the control group will receive conventional antitumor treatment only.

DRUG

Paclitaxel

Patients in the control group will receive conventional antitumor treatment only.

DRUG

Atlizumab

Patients in the control group will receive conventional antitumor treatment only.

Sponsors & Collaborators

  • Peking University Third Hospital

    lead OTHER

Principal Investigators

  • Ming Cui, Doctor · Peking University Third Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-15
Primary Completion
2023-07-01
Completion
2023-12-31

Countries

  • China

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05730777 on ClinicalTrials.gov