Tirofiban After Successful MT Recanalization in AIS

Summary

Acute ischemic stroke with large vessel occlusion is a frequently occurring life-threatening condition. Although endovascular treatment can effectively open occluded vessels, the successful reperfusion rate exceeds 80%, but the rate of good prognosis is less than 50%. The current clinical focus is on how to improve futile recanalization. Tirofiban is widely used in the treatment of stroke, as it can effectively prevent vascular reocclusion and improve microcirculation perfusion. It has the potential to improve futile recanalization, but there is a lack of high-level evidence-based medical support. This multicenter, prospective, double-blind, randomized controlled trial was conducted to assess the effectiveness and safety of sequential tirofiban therapy following successful mechanical thrombectomy within 24 hours of onset.

Conditions

• Acute Ischemic Stroke
• Vessel Occlusion

Interventions

DRUG

Tirofiban

After the completion of endovascular treatment and successful recanalization (mTICI 2b/3), the patients were randomly assigned to the experimental group. Tirofiban 5μg/kg was administered intravenously through the catheter artery at a rate of 1ml/min, followed by an intravenous infusion of 0.1μg/(kg·min) for 24 hours. Standard medical treatment was administered after the surgery.

DRUG

Saline placebo

After the completion of endovascular treatment and successful recanalization (mTICI 2b/3), the patients were randomly assigned to the experimental group. Saline placebo was administered in the same manner as tirofiban group. Standard medical treatment was administered after the surgery.

Sponsors & Collaborators

• Fujian Medical University Union Hospital

  collaborator OTHER

• Jingzhou Hospital Affiliated to Yangtze University

  collaborator UNKNOWN

• Xiangyang No 1 People's Hospital Affiliated to Hubei University of Medicine

  collaborator UNKNOWN

• Puren Hospital Affiliated to Wuhan University of Science and Technology

  collaborator OTHER

• Zhongnan Hospital

  collaborator OTHER

• First Affiliated Hospital of Fujian Medical University

  collaborator OTHER

• Huazhong University of Science and Technology Tongji Medical College Affiliated Wuhan Central Hospital

  collaborator UNKNOWN

• Xianning Central Hospital

  collaborator OTHER

• Shanxi Provincial People's Hospital

  collaborator OTHER_GOV

• The Third People's Hospital of Hubei Province

  collaborator OTHER

• Jingmen Central Hospital

  collaborator UNKNOWN

• Hubei University of Medicine

  collaborator OTHER

• Wuhan No.1 Hospital

  collaborator OTHER

• Nanyang Central Hospital

  collaborator OTHER

• Yichang Central People's Hospital of China Three Gorges University

  collaborator UNKNOWN

• The Central Hospital of Huanggang

  collaborator OTHER

• Zoucheng City People's Hospital

  collaborator UNKNOWN

• Qujing Central Hospital of Yunnan Province

  collaborator UNKNOWN

• Taihe Hospital, Affiliated Hospital of Hubei Province of Medicine

  collaborator UNKNOWN

• Second Affiliated Hospital of Soochow University

  collaborator OTHER

• The First Affiliated Hospital of Nanchang University

  collaborator OTHER

• Central Hospital of Xiaogan

  collaborator OTHER

• The Central Hospital of Enshi Tujia And Miao Autonomous Prefecture

  collaborator OTHER

• Huangshi Central Hospital

  collaborator OTHER

• Zigong No.1 Peoples Hospital

  collaborator OTHER

• Xiangyang Hospital of Traditional Chinese Medicine

  collaborator UNKNOWN

• The First People's Hospital of Jingzhou City

  collaborator UNKNOWN

• The First people's hospital of Xian Yang

  collaborator UNKNOWN

• Jiujiang No.1 People's Hospital

  collaborator OTHER

• Zhongxiang Hospital of Traditional Chinese Medicine

  collaborator UNKNOWN

• Jiangxi Provincial People's Hopital

  collaborator OTHER

• The Lichuan ethnic Hospital of Traditional Chinese Medicine

  collaborator UNKNOWN

• Xiangyang Central Hospital People's Hospital of Huangpi District

  collaborator UNKNOWN

• Quanzhou First Hospital

  collaborator OTHER

• Minda Hospital of Hubei Minzu University

  collaborator UNKNOWN

• The Cerebrovascular Hospital of Hubei Province

  collaborator UNKNOWN

• The First People's Hospital of Changde City

  collaborator OTHER

• Longyan First Affiliated Hospital of Fujian Medical University

  collaborator UNKNOWN

• Xiangzhou People's Hospital

  collaborator UNKNOWN

• Jingmen People's Hospital

  collaborator UNKNOWN

• The First People's Hospital of TianMen in Hubei Province

  collaborator UNKNOWN

• Hanyang Hospital, Wuhan University of Science & Technology

  collaborator UNKNOWN

• Tongcheng People's Hospital

  collaborator UNKNOWN

• Gaoyou People's Hospital

  collaborator UNKNOWN

• Zaoyang First People's Hospital

  collaborator UNKNOWN

• CR & WISCO General Hospital

  collaborator UNKNOWN

• Wuhan Hankou Hospital

  collaborator UNKNOWN

• Lu'an People's Hospital of Anhui Hospital

  collaborator UNKNOWN

• Yingtan People's Hospital

  collaborator UNKNOWN

• Shiyan Renmin Hospital

  collaborator UNKNOWN

• Dali Bai Autonomous Prefecture People's Hospital

  collaborator UNKNOWN

• Three Gorges Hospital of Chongqing University

  collaborator OTHER

• The Second People's Hospital of Jingzhou City

  collaborator UNKNOWN

• General Hospital of the Yangtze River Shipping

  collaborator UNKNOWN

• The Affiliated Hospital Of Southwest Medical University

  collaborator OTHER

• Fujian Provincial Hospital

  collaborator OTHER

• Zhongxiang People's Hospital

  collaborator UNKNOWN

• LiuZhou People's Hospital

  collaborator OTHER

• The Fifth Hospital of Wuhan

  collaborator OTHER

• Xiaogan First People's Hospital

  collaborator UNKNOWN

• Loudi Central Hospital

  collaborator OTHER

• Ezhou Central Hospital

  collaborator UNKNOWN

• Second Xiangya Hospital of Central South University

  collaborator OTHER

• Qingdao Central Hospital

  collaborator OTHER

• Taizhou First People's Hospital

  collaborator OTHER

• Renmin Hospital of Wuhan University

  collaborator OTHER

• Hubei Provincial Hospital of Integrated Chinese & Western Medicine

  collaborator UNKNOWN

• The First Affiliated Hospital of Botou Medical College

  collaborator UNKNOWN

• Xianfeng People's Hospital

  collaborator UNKNOWN

• Wuhan Third Hospital

  collaborator OTHER

• The Fourth Hospital of Wuhan

  collaborator UNKNOWN

• Chengdu Fifth People's Hospital

  collaborator OTHER

• Xingyi People's Hospital

  collaborator UNKNOWN

• Affiliated Hospital of Shandong University of Traditional Chinese Medicine

  collaborator OTHER

• Shenzhen Hospital of Southern Medical University

  collaborator OTHER

• The Third People's Hospital of Jingzhou City

  collaborator UNKNOWN

• The First People's Hospital of Jiangxia District

  collaborator UNKNOWN

• Xihua People's Hospital

  collaborator UNKNOWN

• Shanghai East Hospital

  collaborator OTHER

• Xiang Luo

  lead OTHER

Principal Investigators

• Xiang Luo · Tongji Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-04-09

Primary Completion

2025-12-29

Completion

2025-12-29

Countries

• China

Study Locations