Bioavailability of Different Collagen-based Treatments After Oral Intake

Summary

The goal of this clinical trial is to investigate the postprandial absorption of collagen and elucidate the absorption rate and bioavailability after oral intake of collagen-based products. Participants will be asked to drink solutions containing the study products (one product per group, a total of four products), and blood samples will be obtained by digital puncture at different time points. Plasma will be collected and a set of collagen-derived amino acids, di-peptides and tri-peptides will be quantified by LC-MS. Each product will be compared to the placebo group.

Conditions

• Healthy Volunteers

Interventions

DIETARY_SUPPLEMENT

Dietary supplementation with placebo.

Volunteers will be provided with the placebo. For each volunteer, a blood sample from digital puncture will be obtained, and collagen-derived amino acids, di-peptides and tri-peptides will be quantified by LC-MS.

DIETARY_SUPPLEMENT

Dietary supplementation with the collagen-based product CP1.

Volunteers will be provided with the collagen-derived product CP1. For each volunteer, a blood sample from digital puncture will be obtained, and collagen-derived amino acids, di-peptides and tri-peptides will be quantified by LC-MS.

DIETARY_SUPPLEMENT

Dietary supplementation with the collagen-based product CP2.

Volunteers will be provided with the collagen-derived product CP2. For each volunteer, a blood sample from digital puncture will be obtained, and collagen-derived amino acids, di-peptides and tri-peptides will be quantified by LC-MS.

DIETARY_SUPPLEMENT

Dietary supplementation with the collagen-based product CP3.

Volunteers will be provided with the collagen-derived product CP3. For each volunteer, a blood sample from digital puncture will be obtained, and collagen-derived amino acids, di-peptides and tri-peptides will be quantified by LC-MS.

DIETARY_SUPPLEMENT

Dietary supplementation with the collagen-based product CP4.

Volunteers will be provided with the collagen-derived product CP4. For each volunteer, a blood sample from digital puncture will be obtained, and collagen-derived amino acids, di-peptides and tri-peptides will be quantified by LC-MS.

Sponsors & Collaborators

• Bionos Biotech S.L.

  lead INDUSTRY

Principal Investigators

• David Pajuelo Gamez · Hospital La Fe

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

25 Years

Max Age

45 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-08-01

Primary Completion

2023-09-30

Completion

2023-09-30

Countries

• Spain

Study Locations