Bioavailability and Impact of Coenzyme Q10 in Stressing Exercise in Senescence Athletes

Summary

It is proposed to establish a group of subjects composed of 10 healthy individuals of\> 50 years and \<65, physically active, without metabolic or inflammatory pathology. All of them will undergo a health examination and the physical condition and the absence of contraindication of the sports practice will be characterized through a monitored effort test. Each subject will take a capsule of coenzyme Q10® INDENA for 30 days. The dose to be administered is 100 mg/d of CoQ10 a with food (noon). The state of physical condition and the biochemical and biological variables that reflect oxidative stress and mitochondrial functioning before and after the intervention will be measured.

Conditions

• Coenzyme Q10
• Oxidative Stress
• Aging

Interventions

DIETARY_SUPPLEMENT

Administration of a product with Fitosomed Ubiquinone

Healthy runner athletes, \> 50 years old, without any chronic illness, without any other nutritional supplementation or drug intervention, took 100 mg/d of fitosomed Ubiquinone with lunch, daily, during one month, maintaining their usual training sessions.

PROCEDURE

Coenzyme Q10 level in muscle biopsies

Determination of the muscle Ubiquinone concentration, the metabolic and structure characteristics of the muscle before and after one month of supplementation

DIAGNOSTIC_TEST

Coenzyme Q10 level in plasma, blood cells, urine cells

Determination of Ubiquinone concentration in different tissues before and after one month of supplementation or not

DIAGNOSTIC_TEST

Total antioxidant capacity after strenous exercise

Determination of the Total Antioxidant Capacity after strenous exercise in the Climate Chamber

Sponsors & Collaborators

• Hospital Sant Joan de Deu

  collaborator OTHER

• University of Barcelona

  collaborator OTHER

• Indena S.p.A

  collaborator INDUSTRY

• Centre d'Alt Rendiment

  lead OTHER

Principal Investigators

• Rafael Artuch, MD, PhD · Hospital Sant Joan de Deu, Barcelona

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

50 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2018-03-01

Primary Completion

2018-05-30

Completion

2019-02-28

Countries

• Spain