Optimizing Vancomycin Therapy in Children
NCT05691309 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 29
Last updated 2024-12-20
Summary
The purpose of Opt Vanc is to evaluate the feasibility of Bayesian dose adaptation, based on a previously-developed population pharmacokinetic (PK) model and a single optimally timed PK sample, to predict vancomycin area under the curve (AUC) in critically ill children.
Conditions
- Sepsis
- Critical Illness
- Infections
- Drug Toxicity
Sponsors & Collaborators
-
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
collaborator NIH -
Children's Hospital of Philadelphia
lead OTHER
Eligibility
- Min Age
- 1 Year
- Max Age
- 17 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-12-12
- Primary Completion
- 2023-11-22
- Completion
- 2023-11-22
Countries
- United States
Study Locations
More Related Trials
-
Use of a Loading Dose of Vancomycin in Pediatric Dosing
NCT01290237 ·Status: TERMINATED ·Phase: NA
-
Neonatal Vancomycin Trial
NCT02790996 ·Status: TERMINATED ·Phase: PHASE2
-
Precision Dosing of Vancomycin in Critically Ill Children
NCT04666948 ·Status: COMPLETED ·Phase: PHASE4
-
Vancomycin Dose Adjustments Comparing Trough Levels to The AUC/MIC Method Using a Bayesian Approach in a Hospitalized Adult Population
NCT04756895 ·Status: COMPLETED ·Phase: NA
-
Comparison of Two Dosage Adjustment Strategies of Vancomycin in Children
NCT02694458 ·Status: COMPLETED ·Phase: NA
-
Precision Dosing of Beta-lactam Antibiotics in Critically Ill Children
NCT06929702 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
RCT of Continuous Versus Intermittent Infusion of Vancomycin in Neonates
NCT02210169 ·Status: COMPLETED ·Phase: NA
-
Evaluation of the Dosing Regimen of Vancomycin in Pediatric Patients
NCT03560440 ·Status: COMPLETED
-
External Evaluation of Vancomycin Population Pharmacokinetic Models
NCT05481788 ·Status: COMPLETED
-
Antibiotic Dosing in Pediatric Intensive Care
NCT02456974 ·Status: RECRUITING
-
Clinical Study of Individualized Vancomycin Dosing Based on Population PK Model
NCT06161870 ·Status: RECRUITING ·Phase: PHASE4
-
Evaluation of Pharmacokinetics, Safety, and Tolerability of Ceftazidime-avibactam in Neonates and Infants.
NCT04126031 ·Status: TERMINATED ·Phase: PHASE2
-
Utility of Vancomycin Loading: A Pharmacokinetic Analysis in Critically Ill Patients
NCT01157533 ·Status: TERMINATED ·Phase: NA
-
Reducing Nephrotoxicity of Vancomycin: A Prospective Study of Continuous Versus Intermittent Infusion of Vancomycin
NCT01720940 ·Status: UNKNOWN ·Phase: NA
-
Population Pharmacokinetics of Amikacin in Neonates
NCT04867135 ·Status: COMPLETED
-
Exploring Vancomycin Disposition in Neonates
NCT02096536 ·Status: RECRUITING ·Phase: PHASE4
-
Model-Informed Precision Dosing on Amikacin and Vancomycin Therapy in Critically Ill Children
NCT07315438 ·Status: COMPLETED ·Phase: NA
-
Optimal Dosing of Vancomycin in an Adult Population of Hemato-oncology
NCT04758442 ·Status: UNKNOWN ·Phase: NA
-
Prospective Evaluation of a Vancomycin Nomogram With a Continuous Infusion of Vancomycin for Surgical ICU Patients
NCT01786161 ·Status: TERMINATED ·Phase: PHASE4
-
Optimization of Therapeutic Drug Monitoring of Vancomycin in Pediatric Patients With an Implanted Port Catheter
NCT03720132 ·Status: TERMINATED ·Phase: NA
-
Comparative Effectiveness of Intravenous v. Oral Antibiotic Therapy for Serious Bacterial Infections
NCT02311452 ·Status: COMPLETED
-
PK/PD of Ceftazidime Avitbatan Sodium in Children With Severe Infection
NCT04961580 ·Status: RECRUITING
-
Pharmacokinetics and Safety of Ticarcillin-clavulanate in Infants
NCT01229046 ·Status: WITHDRAWN ·Phase: PHASE1
-
Pharmacokinetics of Vancomycin in Adults Receiving ECMO
NCT00281281 ·Status: COMPLETED ·Phase: PHASE4
-
Dose-finding, Pharmacokinetics, and Safety of VABOMERE in Pediatric Subjects With Bacterial Infections
NCT02687906 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1