MedTrace Logo

Individual Variability of Experimental Gingivitis Response

NCT05656417 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 56

Last updated 2023-10-16

No results posted yet for this study

Summary

The study aims to investigate the genetic cause of the variability between individuals seen in the development of the gum disease, gingivitis. This will be carried out through a 3 week programme where all oral hygiene is ceased, allowing 'experimental gingivitis' to develop, followed by a period of recovery when tooth cleaning is restored. Clinical assessments and biological samples will be taken during the course of the study for further analysis.

Conditions

  • Gingivitis
  • Oral Disease

Interventions

BEHAVIORAL

Temporary cessation of all oral hygiene

Participants will refrain from all oral hygiene for 3 weeks.

Sponsors & Collaborators

  • Unilever R&D

    collaborator INDUSTRY

  • Guy's and St Thomas' NHS Foundation Trust

    collaborator OTHER

  • Biotechnology and Biological Sciences Research Council

    collaborator OTHER

  • King's College London

    lead OTHER

Principal Investigators

  • Luigi Nibali, PhD · King's College London

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-19
Primary Completion
2025-07-31
Completion
2025-07-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05656417 on ClinicalTrials.gov