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Diagnostic Performance of Low-Dose CT for Acute Abdominal Conditions

NCT05651360 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 246

Last updated 2026-05-19

No results posted yet for this study

Summary

The goal of this non-inferiority observational study is to assess the diagnostic performance of low-dose CT with deep learning image reconstruction (DLIR) in adult participants with acute abdominal conditions. The main research question is:

• Can low-dose CT with DLIR achieve the same diagnostic performance as standard CT for the diagnosis of acute abdominal conditions.

Participants will be examined with an additional low-dose CT directly after the standard CT. Participant will be their own controls.

Registration record updated on 15.05.2026 to correct entry errors (correction of sample size calculation now resulting in a larger sample size than previously stated, mixed-effects logistic regression was used for analysis of the diagnostic accuracy) so that the record reflects the study protocol in effect before enrollment of the first participant.

Conditions

Interventions

DIAGNOSTIC_TEST

low-dose CT

Low-dose CT scan will be performed, not exceeding 30% radiation dose of the standard CT. Low-dose CT images will be reconstructed with TrueFidelity high. The low-dose CT will be performed directly after the standard CT to avoid bias from differences in the timing of the contrast phase.

Sponsors & Collaborators

  • Odense University Hospital

    collaborator OTHER

  • Oslo University Hospital

    lead OTHER

Principal Investigators

  • Anselm Schulz, PhD · Oslo University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-12-07
Primary Completion
2023-07-10
Completion
2023-07-10

Countries

  • Denmark
  • Norway

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05651360 on ClinicalTrials.gov