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A Longitudinal Study to Identify Mechanisms of Menopause on Cardiovascular Disease Risk

NCT05647876 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2023-05-10

No results posted yet for this study

Summary

With the cessation of estrogen production at menopause, the risk of cardiovascular disease like arthrosclerosis, myocardial infarction and stroke increases dramatically. Physical activity is the single most powerful "drug" for maintaining and improving cardiovascular health, but recent data suggest that the positive effect of physical activity is lost at menopause. In this project the investigators will follow a cohort of 200 women from before the women enter menopause and until at least 10 years past menopause. By advanced invasive methodologies the investigators will monitor the changes that occur in the blood vessels of the circulation, the heart and the brain and combine this with microRNA sequencing of blood and tissue samples.

Conditions

Sponsors & Collaborators

  • University of Copenhagen

    lead OTHER

Principal Investigators

  • Lasse Gliemann, PhD · Department of Nutrition, Exercise and Sports, University of Copenhagen, 2200 Copenhagen, Denmark

Eligibility

Min Age
40 Years
Max Age
61 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-12-16
Primary Completion
2040-12-31
Completion
2045-08-31

Countries

  • Denmark

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05647876 on ClinicalTrials.gov