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Effect of Local Cannabidiol on Clinical and Inflammatory Outcomes in Periodontal Maintenance Patients.

NCT05646459 · Status: WITHDRAWN · Phase: PHASE1 · Type: INTERVENTIONAL

Last updated 2024-09-03

No results posted yet for this study

Summary

This study will determine if cannabidiol (CBD) has any effect on local inflammation in periodontal maintenance patients. Many successful therapies exist for the active, untreated periodontal patient. Unfortunately, periodontology has not yet discovered a therapy that will predictably treat local inflammation in patients who are at risk for further pocketing, bleeding on probing, bone loss and ultimately, tooth loss. Although CBD has been patented in various forms since the 1940s, its acceptance and availability to patients has only recently expanded. Marketing of CBD to periodontal patients as a means to control inflammation is commonplace online and in CBD-specific shops. In determining if CBD is a successful supplement to conventional periodontal inflammation control therapies, millions of patients could benefit from this treatment.

Conditions

  • Periodontitis, Adult
  • Inflammation Gum

Interventions

DRUG

cannabidiol

This group will locally apply cannabidiol to a posterior, localized 6-9 mm bleeding periodontal pocket.

DEVICE

floss

This group will use floss alone at the test site (posterior, localized 6-9 mm bleeding periodontal pocket).

DEVICE

proxabrush

This group will use floss alone at the test site (posterior, localized 6-9 mm bleeding periodontal pocket).

Sponsors & Collaborators

  • University of Nebraska

    lead OTHER

Principal Investigators

  • Joseph B Bavitz, DMD · UNMC College of Dentistry

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-05-14
Primary Completion
2020-05-14
Completion
2020-05-14
FDA Drug
Yes

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05646459 on ClinicalTrials.gov