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Extracellular Vesicles and Dysregulated Coagulation in the Prediction of Stroke

NCT05645081 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 360

Last updated 2024-08-20

No results posted yet for this study

Summary

Annually 100,000 strokes occur, placing stroke as the largest cause of disability in the UK. 90% of strokes are preventable, leading to national focus on programmes including "The National Stroke Programme" to act on preventing, treating, and improving post-stroke care. Importantly, over 25% of ischaemic stroke sufferers have previously had a Transient Ischaemic Attack (TIA), which presents the biggest concern for TIA patients. There are no measures which reliably identify TIA patients most likely to suffer a stroke. Novel biomarkers for predicting stroke are key to addressing this problem. The PREDICT-EV study aims to screen 300 TIA patients and follow them over 12-months. The investigators will determine if a novel biomarker we've identified to increase thrombotic risk (endothelial derived extracellular vesicles) and the resulting increased prothrombin time is associated with patients at highest risk of stroke.

Conditions

  • Stroke, Ischemic
  • Transient Ischemic Attack
  • Coagulation Disorder

Sponsors & Collaborators

  • Cardiff Metropolitan University

    collaborator OTHER

  • Cwm Taf University Health Board (NHS)

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-10-01
Primary Completion
2026-09-01
Completion
2027-09-01

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05645081 on ClinicalTrials.gov