Evaluation of the Effect of Periimplant Soft Tissue Phenotype on Marginal Bone Loss

Summary

The goal of this clinical trial to test the effect of periimplant soft tissue phenotype in the participants with implant placed and at least 1 year after implant loading. The main questions it aims to answer are:

1. Is keratinized mucosal thickness (KMT) important in early marginal bone loss and peri implant health?
2. Is keratinized gingival width (KGW) important in early marginal bone loss and and peri implant health? The researchers plan to include 80 implants in the study. These 80 implants will be divided into 2 groups in 2 different ways according to their KMT and KGW on their buccal surfaces: KMT ≥2 mm are included in the adequate KMT, and those with KMT\<2 mm are in the insufficient KMT group. Those with KGW≥2 mm are adequate KGW, those with KGW\<2 mm are adequate KGW. The researchers will assess marginal bone loss around the implant using radiographs and collect peri-implant crevicular fluid (PICF) using paper strips. Another researchers will measure the Receptor Activator Of Nuclear Factor-Kappa B Ligand (RANKL), Osteoprotegerin (OPG), Tumor Necrosis Factor Alpha (TNF-α), MicroRNA-223 (MiRNA-223), MicroRNA-27a (MiRNA-27a) levels in the collected PICF. They will compare radiographic bone loss and biomarker levels in groups.

Conditions

• Alveolar Bone Loss
• Dental Implant
• Periimplantitis

Interventions

DIAGNOSTIC_TEST

Nuclear Factor-Kappa B Ligand (RANKL) analysis

samples of peri-implant groove fluid will be taken with paper strips and RANKL assessment will be made

DIAGNOSTIC_TEST

Osteoprotegerin (OPG) analysis

samples of peri-implant groove fluid will be taken with paper strips and OPG assessment will be made

DIAGNOSTIC_TEST

Tumor Necrosis Factor Alpha (TNF-α) analysis

samples of peri-implant groove fluid will be taken with paper strips and TNF-α assessment will be made

DIAGNOSTIC_TEST

MicroRNA-223 analysis

samples of peri-implant groove fluid will be taken with paper strips and MicroRNA-223 assessment will be made

DIAGNOSTIC_TEST

Microrna-27a analysis

samples of peri-implant groove fluid will be taken with paper strips and Microrna-27a assessment will be made

Sponsors & Collaborators

• Necmettin Erbakan University

  lead OTHER

Principal Investigators

• zeynep taştan eroğlu · Necmettin Erbakan University

• dilek özkan şen · Necmettin Erbakan University

• elif öncü · Lokman Hekim University

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-12-02

Primary Completion

2023-01-15

Completion

2023-01-15

Countries

• Turkey (Türkiye)

Study Locations