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Relative Importance of Cardiovascular Risk Factors and Echocardiographic Parameters Affecting Left Atrial Strain

NCT05638230 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 2500

Last updated 2022-12-06

No results posted yet for this study

Summary

The goal of this observational study is to learn about left atrial reservoir strain in patients with heart failure with preserved ejection fraction. The main questions it aims to answer are:

* Usefullness of LARS as a predictor of high HFA-PEFF diagnostic algorithm scores (≥5)
* The relative importance of LARS in variables including each component of HFA-PEFF and traditional cardiovascular risk factors.

Conditions

  • Heart Failure, Diastolic
  • Heart Failure, Preserved Ejection Fraction

Interventions

DIAGNOSTIC_TEST

Left atrial reservoir strain

LA strain measurements can be obtained by two dimensional (2D) speckle tracking echocardiography (STE). Longitudinal strain and strain rate curves are generated for each of six atrial segments, obtained from the apical four and two chamber views. In the reservoir phase, as the LA fills and stretches, there is positive atrial strain that reaches its peak in systole at the end of LA filling, prior to opening of the mitral valve. Following this, passive LA emptying ensues with opening of the mitral valve resulting in decreased atrial strain with negative deflection of the strain curve up to a plateau period which is analogous to diastasis. LA reservoir strain (LARS), or peak atrial longitudinal strain or LA systolic strain, is measured at the end of the reservoir phase.

Sponsors & Collaborators

  • Yonsei University

    lead OTHER

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-08-01
Primary Completion
2023-07-31
Completion
2025-07-31

Countries

  • South Korea

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05638230 on ClinicalTrials.gov