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Right Ventricular Function and Pulmonary Hypertension in HFpEF

NCT05055180 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2021-09-24

No results posted yet for this study

Summary

In patients with heart failure and preserved ejection fraction (HFpEF) right ventricular (RV) systolic and diastolic dysfunction are prognostically and functionally relevant factors but have mechanistically been neglected so far. In the present study alterations of intrinsic RV (systolic and diastolic) function, as assessed by invasive pressure volume loops, are examined in relation to tissue alterations on myocardial level and to the degree of RV afterload (pulmonary hypertension). Study aim is to gain insights into mechanisms contributing to the development of RV dysfunction and potentially identify new therapeutic targets.

Conditions

Interventions

DIAGNOSTIC_TEST

Invasive hemodynamics and myocardial biopsies

Invasive hemodynamic characterization (biventricular pressure volume loop assessment) and biventricular myocardial biopsies

Sponsors & Collaborators

  • University Hospital Tuebingen

    collaborator OTHER

  • University Hospital Muenster

    collaborator OTHER

  • Heart Center Leipzig - University Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-10-01
Primary Completion
2021-11-30
Completion
2021-12-30

Countries

  • Germany

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05055180 on ClinicalTrials.gov