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All Eyes on PCS - Analysis of the Retinal Microvasculature in Patients With Post-COVID-19 Syndrome

NCT05635552 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2022-12-02

No results posted yet for this study

Summary

The goal of this observational, prospective study is to in depth analyze the retinal microvasculature in patients with Post-COVID-19 Syndrome (PCS). The main questions it aims to answer is:

Do patients with PCS show a prolonged endothelial dysfunction when compared with fully COVID-19 recovered participants? Does symptom severity in PCS patients correlate with the extend of endothelial dysfunction? Do these changes correlate with improvement in symptoms in the prospective observation?

Conditions

  • Long Covid19
  • Post COVID-19 Condition
  • Endothelial Dysfunction

Interventions

DIAGNOSTIC_TEST

Dynamic retinal vessel analysis (DVA)

DVA is an established, non-invasive tool to measure the responsiveness of retinal vessels to flickering light. In addition static retinal vessel parameters are recorded.

DIAGNOSTIC_TEST

Optical coherence tomography (OCT)

OCT is an imaging technique which applies low-coherence light to capture high resolution images from the ocular fundus.

DIAGNOSTIC_TEST

Biochemistry and immune phenotyping

Blood sample collection for clinical chemistry and isolation of PBMCs for FACS analysis.

DIAGNOSTIC_TEST

Handgrip strength test

Measure the maximum isometric strength of the hand and forearm muscles and their fatiguability.

DIAGNOSTIC_TEST

Questionnaires (Patient reported outcomes)

The questionnaires evaluate anxiety, depression, chronic fatigue, quality of life, and post-covid typical symptoms

Sponsors & Collaborators

  • Ludwig-Maximilians - University of Munich

    collaborator OTHER

  • Technical University of Munich

    lead OTHER

Principal Investigators

  • Christoph Schmaderer, Prof. Dr. · Technical University Munich

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-10-17
Primary Completion
2023-02-21
Completion
2023-07-21

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05635552 on ClinicalTrials.gov