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Diagnostic and Prognostic Value of Lung Microbiota in Early Lung Infection After Lung Transplantation

NCT05627505 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2022-11-25

No results posted yet for this study

Summary

The present study is a prospective case-control study. Patients were enrolled post lung transplantation and alveolar lavage fluid was obtained within 48 hours of the patient's surgery, divided into aliquots and subjected to macrogenomic sequencing, routine microbiological testing and cytokine testing. Patients were divided into pulmonary infection and non-pulmonary infection groups based on whether they had a co-infection at the time of sampling. Pulmonary infection was used as the primary study endpoint. To describe and compare the characteristics of the lung microbiota in the two groups and to determine whether variation in the lung microbiota could predict the development of lung infection and prognosis in patients in the early post-transplant period.

Conditions

Interventions

DIAGNOSTIC_TEST

metagenomic next-generation sequencing

Collection of bronchoalveolar lavage fluid

Sponsors & Collaborators

  • Qingyuan Zhan

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-11-20
Primary Completion
2023-11-30
Completion
2023-12-30

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05627505 on ClinicalTrials.gov