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Low Dose Vitamin C in Burns >20% Compared to Previous Studies With High Dose Vitamin C

NCT05612867 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 54

Last updated 2022-11-10

No results posted yet for this study

Summary

Burn injury is marked by a large release of inflammatory mediators which disrupt the normal capillary barrier and cause a rapid shift of intravascular fluid into interstitial spaces, ultimately leading to shock and death. As such, adequate fluid management and resuscitation is critical for burn patients to prevent further cellular injury. Technologies and medical options such as cardiac output monitoring along with early tube feeding and vitamin C administration have developed slowly over the years. Effective management of the Systemic Inflammatory Response Syndrome response and metabolic derangement is crucial for the survival of burn patients. In particular, vitamin C administration has shown to significantly decreases early post-burn lipid peroxidation, reduce microvascular leak of fluid by preventing endothelial dysfunction, and decreases edema formation in burned tissue. Vitamin C is a cheap and widely available antioxidant which has been shown to significantly effective in positively impacting clinical outcomes in burn resuscitation. We aim to evaluate the efficacy of vitamin C in burns greater than 20% total body surface area on clinical outcomes such as length of hospital stay, total fluid requirements, and mortality.

Conditions

  • Burns
  • Ascorbic Acid Deficiency
  • Burn Shock
  • Burn Degree Second
  • Burn Degree Third
  • Fluid and Electrolyte Imbalance

Interventions

DIETARY_SUPPLEMENT

Vitamin C

Due to clinical research supporting high dose vitamin C, the institution's surgical intensivists started utilizing a high IV vitamin C dose in higher total body surface area burns while continuing to use the standard PO vitamin C dose of 500 mg to 1,000 mg daily on patients with lower total body surface area burns. Looking at the initial 72 hours, patients with smaller burns were given 2,500 mg PO vitamin C and larger total body surface area burns were given 15,000 mg IV vitamin C.

Sponsors & Collaborators

  • Arrowhead Regional Medical Center

    lead OTHER

Principal Investigators

  • Aldin Malkoc, MD · Arrowhead Regional Medical Center

  • David T Wong, MD · Arrowhead Regional Medical Center

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-12
Primary Completion
2021-01-08
Completion
2021-01-08

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05612867 on ClinicalTrials.gov