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Effect of Single High Dose of Cholecalciferol on Serum Metabolites of Vitamin D

NCT05591170 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 58

Last updated 2023-02-09

No results posted yet for this study

Summary

The aim of this interventional study is to assess the effect of the single high dose of vitamin D on its serum metabolites in elderly.

The main questions it attempts to answer is:

1. what is the effect of a single, high, oral dose of vitamin D3 (120,000 IU) on serum 25(OH)D3, 25(OH)D2, 24,25(OH)2D3, 3-epi-25(OH)D3, 1,25(OH)2D3, 24,25(OH)2D3/25(OH)D3 ratio, and 25(OH)D3/3-epi-25(OH)D3 ratio concentration at baseline, 3 days and 7 days after administration, compared to control group.
2. what is the influence of percentage of fat tissue on serum metabolites of vitamin D and their changes after bolus dose, compared to control group.

Conditions

  • Vitamin D Deficiency

Interventions

DRUG

Cholecalciferol 120 000 IU

single, oral administration of high dose of vitamin D

Sponsors & Collaborators

  • Department of Endocrinology, Centre of Postgraduate Medical Education

    lead OTHER

Principal Investigators

  • Wojciech Zgliczyński, Prof. · Department of Endocrinology, Centre of Postgraduate Medical Education

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-04-01
Primary Completion
2021-08-31
Completion
2021-08-31

Countries

  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05591170 on ClinicalTrials.gov