Effect of Vitamin D Oral Supplements on 25 OH Vitamin D Levels

Summary

Vitamin D deficiency is common world wide. 25 OH vitamin D level is the best indicator of vitamin D status. Vitamin D supplements are available as vitamin D2 or D3, in small daily or large weekly/monthly doses. Controversy continues on the relative potency of vitamin D2 compared to D3 and of daily compared to weekly or monthly doses, in increasing/maintaining total 25 OH vitamin D level.

The investigators plan to conduct a controlled trial to compare the effect of various vitamin D supplements on 25 OH vitamin D levels in healthy adults with starting 25 OH vitamin D level between 20 to 50 nmol/L.

Conditions

• Vitamin D Deficiency

Interventions

DRUG

ergocalciferol 2000 IU orally, daily

ergocalciferol 2000 IU orally, daily

DRUG

ergocalciferol 25000 IU oraly every 2 weeks

ergocalciferol 25000 IU oraly every 2 weeks

DRUG

ergocalciferol 50000 IU orally every 4 weeks

ergocalciferol 50000 IU orally every 4 weeks

DRUG

ergocal1000 IU & cholecal 1000 IU orally daily

ergocalciferol 1000 IU and cholecalciferol 1000 IU orally every day

DRUG

cholecalciferol 2000 IU orally daily

cholecalciferol 2000 IU orally everyday

DRUG

Cholecalciferol 25000 IU orally every 2 weeks

Cholecalciferol 25000 IU orally every 2 weeks

DRUG

Cholecalciferol 50000 orally every 4 weeks

Cholecalciferol 50000 orally every 4 weeks

DRUG

placebo orally everyday

placebo orally everyday

Sponsors & Collaborators

• King Faisal Specialist Hospital & Research Center

  lead OTHER

Principal Investigators

• Muhammad M Hammami, MD, PhD · King Faisal Specialist Hospital & Research Center

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-02-28

Primary Completion

2016-04-30

Completion

2016-04-30

Countries

• Saudi Arabia

Study Locations