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TB Case-Finding, Treatment and Prevention Intervention in Thailand

NCT05581212 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 7455

Last updated 2026-04-29

No results posted yet for this study

Summary

The project aimed to test a strategy for the early detection and prevention of tuberculosis in household contacts of tuberculosis patients in order to reduce the morbidity, mortality and transmission of this disease in Thailand. This strategy will be evaluated in comparison with the current programmatic approach through a pragmatic trial with cluster randomization (cluster randomized controlled trial) which will be conducted over the next 3 years. This project is carried out in collaboration with the Tuberculosis Division of the Ministry of Public Health of Thailand, the TB/HIV Research Foundation in Thailand and the London School of Hygiene and Tropical Medicine in England.

Conditions

Interventions

OTHER

Tuberculosis Case-Finding, Treatment and Prevention Public Health Pack

Combined active case-finding, treatment and prevention of TB amongst HH contacts of TB cases, associated with initiation of standard of care (SOC) treatment in active TB cases and initiation of TB preventive therapy in those contacts without active TB, based on free screening. This intervention will be compared to the standard of care available in the country.

Sponsors & Collaborators

  • Ministry of Health, Thailand

    collaborator OTHER_GOV

  • Tuberculosis and HIV Research Foundation

    collaborator UNKNOWN

  • London School of Hygiene and Tropical Medicine

    collaborator OTHER

  • Institut de Recherche pour le Developpement

    lead OTHER_GOV

Principal Investigators

  • Christian Lienhardt · Institut de Recherche pour le Developpement

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
SEQUENTIAL

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-05-07
Primary Completion
2026-01-06
Completion
2026-01-07

Countries

  • Thailand

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05581212 on ClinicalTrials.gov