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Effectiveness of PRP, Conditioned Medium UC-MSCs Secretome and Hyaluronic Acid for the Treatment of Knee Osteoarthritis

NCT05579665 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2026-05-22

Study results available
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Summary

The clinical trial will be carried out at the Dr. Moh. Hoesin Central Hospital, Palembang and planned from October 2022 to March 2023.

This study aims to compare the efficacy of Platelet Rich Plasma, Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell (MSC) Culture Secretome and hyaluronic acid for the Treatment of Knee Osteoarthritis

Conditions

Interventions

BIOLOGICAL

Platelet-rich Plasma

Research participants own blood will be used to prepare the platelet rich plasma injectate.

BIOLOGICAL

Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell Culture (MSCs) Secretome

Conditioned Medium UC-MSCs Secretome which will be injected into the affected knee using ultrasound guidance.

DRUG

Low Molecular Weight Hyaluronic Acid

low molecular weight hyaluronic acid which will be injected into the affected knee using ultrasound guidance.

Sponsors & Collaborators

  • Dr. Mohammad Hoesin Central General Hospital

    collaborator UNKNOWN

  • Universitas Sriwijaya

    lead OTHER

Principal Investigators

  • Radiyati U Partan, MD · Universitas Sriwijaya

  • Surya Darma, MD · Universitas Sriwijaya

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-10-02
Primary Completion
2023-03-31
Completion
2023-05-31

Countries

  • Indonesia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05579665 on ClinicalTrials.gov