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The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study

NCT05574400 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 250

Last updated 2026-04-21

No results posted yet for this study

Summary

The objective of this study is to test the effects of caffeine on neurocognitive and clinical recovery after major surgery. Specifically, this trial tests the primary hypothesis that caffeine will reduce the incidence of postoperative delirium.

Conditions

Interventions

DRUG

Dextrose Water

Dextrose 5% in water

DRUG

Caffeine citrate

Low-dose caffeine citrate (1.5 mg/kg)

DRUG

Caffeine citrate

High-dose Caffeine citrate (3 mg/kg)

Sponsors & Collaborators

Principal Investigators

  • Phillip Vlisides, MD · Assistant Professor of Anesthesiology

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-20
Primary Completion
2026-04-16
Completion
2026-05-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05574400 on ClinicalTrials.gov