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Dexmedetomidine or Clonidine Infusion for Prevention of Delirium After Open Heart Surgery

NCT05029050 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 900

Last updated 2024-04-30

No results posted yet for this study

Summary

A parallel-group treatment, five-centre, participant and investigator masked, three-arm study to assess the safety and effectiveness of dexmedetomidine or clonidine infusion compared to placebo for the prevention of delirium and cognitive decline in male and female participants aged 70+ scheduled for open heart surgery.

Conditions

Interventions

DRUG

Dexmedetomidine

Continous intravenous infusion

DRUG

Clonidine

Continous intravenous infusion

DRUG

Natriumchlorid

Continous intravenous infusion NaCl

Sponsors & Collaborators

  • Haukeland University Hospital

    collaborator OTHER

  • University Hospital of North Norway

    collaborator OTHER

  • UMC Utrecht

    collaborator OTHER

  • Sahlgrenska University Hospital

    collaborator OTHER

  • St. Olavs Hospital

    collaborator OTHER

  • Oslo University Hospital

    lead OTHER

Principal Investigators

  • Bjørn Erik Neerland, PhD · Oslo University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-17
Primary Completion
2024-07-31
Completion
2025-01-31

Countries

  • Norway

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05029050 on ClinicalTrials.gov