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Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI

NCT05525845 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2025-09-18

No results posted yet for this study

Summary

The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.

Conditions

  • Healthy

Interventions

OTHER

Functional Magnetic Resonance Imaging (pCASL-MRI)

MRI's will be performed at multiple points on each visit day.

OTHER

Intragastric Balloon

Intragastric Balloon will be placed during Visit 2 study day and inflated to maximum tolerated volume. Patient will then be scanned in the MRI.

OTHER

Elemental Meal

Patient will ingest the tasteless elemental meal until their maximum level of fullness. Once full, the patient will be scanned in the MRI.

OTHER

Hedonic Meal

Patient will ingest meal of their choice from a local food delivery service and eat until they reach their maximum level of fullness. Once full, the patient will be scanned in the MRI

Sponsors & Collaborators

Principal Investigators

  • Andres Acosta, MD, PhD · Mayo Clinic

Study Design

Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
21 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-09-08
Primary Completion
2028-08-31
Completion
2028-08-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05525845 on ClinicalTrials.gov