Metabolic Imaging of Neurological Disease
NCT06900244 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 250
Last updated 2025-03-28
Summary
Multiple Sclerosis is a chronic condition that shows changes in the way that the brain consumes sugar. It is also known that there are a number of metabolic and inflammatory sequelae following a transient ischemic attack/stroke (hereby referred to collectively as 'stroke'). This study will use a powerful new technology ('hyperpolarised magnetic resonance imaging') to detect these changes in the brains of people with multiple sclerosis and Clinically Isolated Syndrome (CIS) or following a stroke when compared to a group of healthy volunteers. It will be undertaken at the University of Oxford, and each participant will undergo up to 4 scans over the course of three years.
Conditions
Sponsors & Collaborators
-
University of Oxford
lead OTHER
Eligibility
- Max Age
- 99 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2021-07-01
- Primary Completion
- 2027-06-30
- Completion
- 2027-06-30
Countries
- United Kingdom
Study Locations
More Related Trials
-
Dysregulated CNS Inflammation After Acute Brain Injury
NCT03287557 ·Status: COMPLETED
-
Neuroimaging & Plasma Markers for Predicting Outcomes After Mild Traumatic Brain Injury
NCT02891941 ·Status: TERMINATED
-
Magnetic Resonance Imaging to Detect Brain Damage in Patients With Multiple Sclerosis
NCT00321568 ·Status: COMPLETED
-
Non-invasive Clinical Imaging of Cerebral Metabolism Following Brain Injury Using 13C Magnetic Resonance Spectroscopy.
NCT02745210 ·Status: TERMINATED ·Phase: NA
-
Mobile MRI for Immediate Radiological Acute Cerebral Lesion Evaluation in Stroke
NCT06262217 ·Status: RECRUITING
-
MR Perfusion Imaging and Hypercapnia (Increased Carbon Dioxide) to Study New Blood Vessel Formation in Multiple Sclerosis
NCT00064909 ·Status: COMPLETED
-
Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders
NCT05982925 ·Status: ENROLLING_BY_INVITATION
-
Detecting Traumatic Intracranial Hemorrhage With Microwaves and Biomarkers
NCT04666766 ·Status: RECRUITING ·Phase: NA
-
Assessing Brain Injury Using Portable Magnetic Resonance Imaging (MRI)
NCT05469139 ·Status: COMPLETED
-
Objective Brain Function Assessment of mTBI/Concussion in College Athletes
NCT02477943 ·Status: COMPLETED
-
Functional MRI Biomarkers of Cognitive Decrements in Diabetes
NCT01705210 ·Status: COMPLETED
-
Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis
NCT00432900 ·Status: COMPLETED ·Phase: PHASE1
-
High-resolution Multi-parametric Magnetic Resonance Imaging for Focal Epilepsy
NCT06550726 ·Status: RECRUITING ·Phase: NA
-
Assessing Brain Metabolism Using MRS With Deuterated Glucose
NCT06594315 ·Status: ACTIVE_NOT_RECRUITING
-
Evaluation of Optical Pumping Magnetometer Sensors for MagnetoEncephaloGraphy Imaging
NCT04694313 ·Status: COMPLETED ·Phase: NA
-
Contrast-enhanced 3D T1-weighted Gradient-echo Versus Spin-echo 3 Tesla MR Sequences in the Detection of Active Multiple Sclerosis Lesions
NCT03268239 ·Status: COMPLETED ·Phase: NA
-
Molecular Imaging of NET Using [C-11]MRB-PET in MS
NCT03207464 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status Epilepticus
NCT06017973 ·Status: RECRUITING ·Phase: NA
-
Measuring Cerebral Blood Flow Using Pseudo-continuous Arterial Spin Labeling Perfusion Magnetic Resonance Imaging
NCT02767609 ·Status: COMPLETED ·Phase: NA
-
Investigation of GM Pathology Using Ultra High Field (7T) MRI Scanner
NCT01805986 ·Status: UNKNOWN
-
Diffusion-weighted MRI to Predict Treatment Response in Stereotactic Radiotherapy of Central Nervous System (CNS) Metastases
NCT04700748 ·Status: UNKNOWN ·Phase: NA
-
TSPO-PET/MRI in Surveillance of Neuroinflammation in the Central Nervous System
NCT06467773 ·Status: RECRUITING
-
Evaluating the Remote Effects of Stroke With MRI and PET Scans
NCT00063180 ·Status: COMPLETED
-
MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets
NCT04073966 ·Status: RECRUITING
-
Objective Brain Function Assessment of mTBI/Concussion in High School Athletes
NCT02661633 ·Status: COMPLETED