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MRI Based Study to Assess Brain-gut Axis in Obesity

NCT05437653 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2022-06-29

No results posted yet for this study

Summary

The mechanism of neural communication between the brain and gut in the regulation of food intake is complex and not fully understood. Magnetic Resonance Imaging (MRI) is a powerful non-invasive imaging tool that allows studying the function of the brain and gut. The aim of this study is to develop MRI methods to combine brain and gut imaging in a single MRI scan session. The developed techniques will then be used to assess the brain-gut axis to a high fat drink compared with iso-caloric/iso-viscous/iso-volumetric carbohydrate drink in people with obesity and healthy weight participants. The findings could provide a possible explanation for why some people are heavier than others.

Conditions

Interventions

OTHER

Nutritional Drink A

300 mL of a 22% high fat emulsion (Rapeseed oil, water, emulsifier)

OTHER

Nutritional Drink B

300 mL of isocaloric, iso-volumetric and iso-viscous carbohydrate drink (maltodextrin)

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Sally Eldeghaidy, PhD · University of Nottingham

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-28
Primary Completion
2023-04-01
Completion
2023-12-30

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05437653 on ClinicalTrials.gov