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Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome

NCT05521958 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2026-04-29

No results posted yet for this study

Summary

The purpose of this study is to evaluate both genotypic differences and differences in local gene expression in individuals who develop acute traumatic compartment syndrome relative to control patients with at-risk lower extremity fractures who do not develop compartment syndrome.

Conditions

  • Tibial Shaft Fracture
  • Tibial Plateau Fracture

Interventions

PROCEDURE

Acute injury without compartment syndrome

Acute tibial shaft or tibial plateau fractures who do not have clinical compartment syndrome. Muscle punch biopsy of the anterior compartment will be taken.

PROCEDURE

Acute injury with compartment syndrome

Acute tibial shaft or tibial plateau fractures who have clinical compartment syndrome. Muscle punch biopsy of the anterior compartment will be taken.

PROCEDURE

Exertional compartment syndrome

For patients with exertional compartment syndrome, a muscle biopsy will be obtained from affected extremity.

Sponsors & Collaborators

Principal Investigators

  • Justin Haller, M.D. · University of Utah Orthopaedics

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-10
Primary Completion
2028-06-30
Completion
2028-06-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05521958 on ClinicalTrials.gov