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Split-belt Treadmill Training for Freezing of Gait in Parkinson's Disease

NCT05511597 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2026-03-19

No results posted yet for this study

Summary

A split-belt treadmill (SBT) is a treadmill with two belts, whereby each leg can be driven at a different speed. Previous work by the investigators showed that one session of SBT training improved turning while multi-tasking and reduced FOG in PwPD tested in the laboratory. However, subsequent work raises questions as to whether treadmill improvements following repeated SBT training generalize to overground situations in the long term. Therefore, in this study, the investigators will perform a four-week SBT intervention with added practice of everyday turning scenarios (SBT+CP) or placebo exercise (SBT+PL), and study its effects on FOG in both the laboratory and at home.

Conditions

  • Parkinson Disease
  • Freezing of Gait
  • Split-belt Treadmill

Interventions

BEHAVIORAL

Split-belt treadmill training

Split-belt walking with various speed ratios between the two legs, applied with random-block practice

BEHAVIORAL

Complex task practice

Overground gait flexibility training with added cognitive tasks

BEHAVIORAL

Static balance exercise

Mindfulness and breathing combined with static balance exercises

Sponsors & Collaborators

  • KU Leuven

    lead OTHER

Principal Investigators

  • Alice Nieuwboer, PhD · KU Leuven

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-12-16
Primary Completion
2025-10-31
Completion
2026-03-17

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05511597 on ClinicalTrials.gov