Best Revascularisation Approach for Posterior Circulation Strokes With Isolated Vertebral Artery Occlusions

Summary

Isolated vertebral artery occlusions (VAO) account for approximately one third of posterior circulation occlusions, but have been given the least attention among posterior circulation strokes. If the two recent ATTENTION and BAOCHE randomized clinical trials have proven the superiority of endovascular thrombectomy (EVT) in basilar artery occlusions, data on the effectiveness and harm of acute revascularization treatment on isolated VAO is scarce. We aim to investigate the impact of acute recanalisation treatments in acute ischemic stroke patients with isolated VAO.

In the absence of RCT, observational data with appropriate statistical methods may give indications on benefits and harms of treating neglected stroke situations like acute vertebral occlusion. Results may also lay the basis for prospective studies, such as randomized clinical trials.

Conditions

• Ischemic Stroke
• Vertebral Artery Ischemia
• Arterial Occlusive Diseases
• Vertebrobasilar Insufficiency

Interventions

OTHER

Conservative treatment (CT)

Best medical treatment without intravenous thrombolysis nor endovascular thrombectomy

OTHER

Intravenous thrombolysis (IVT)

Best medical treatment with intravenous thrombolysis but without endovascular thrombectomy

OTHER

Endovascular thrombectomy (EVT) ± intravenous thrombolysis (IVT)

Best medical treatment with endovascular thrombectomy with or without intravenous thrombolysis

Sponsors & Collaborators

• Asan Medical Center

  collaborator OTHER

• St John of God Hospital, Vienna

  collaborator OTHER

• Medical University Innsbruck

  collaborator OTHER

• Hospital Vall d'Hebron

  collaborator OTHER

• University Hospital, Basel, Switzerland

  collaborator OTHER

• Clinical Centre of Serbia

  collaborator OTHER

• Charite University, Berlin, Germany

  collaborator OTHER

• Insel Gruppe AG, University Hospital Bern

  collaborator OTHER

• Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

  collaborator OTHER

• Boston Medical Center

  collaborator OTHER

• Università degli Studi di Brescia

  collaborator OTHER

• The Cooper Health System

  collaborator OTHER

• University Hospital Carl Gustav Carus

  collaborator OTHER

• Duke University

  collaborator OTHER

• University Hospital, Geneva

  collaborator OTHER

• Hadassah Medical Organization

  collaborator OTHER

• Sahlgrenska University Hospital

  collaborator OTHER

• Universitätsklinikum Hamburg-Eppendorf

  collaborator OTHER

• Helsinki University Central Hospital

  collaborator OTHER

• The University of Texas Health Science Center, Houston

  collaborator OTHER

• University Hospital, Lille

  collaborator OTHER

• Hospital de Egas Moniz

  collaborator OTHER

• Neurocenter of Southern Switzerland

  collaborator OTHER

• Spectrum Health Hospitals

  collaborator OTHER

• Azienda Ospedaliero-Universitaria di Modena

  collaborator OTHER

• Ludwig-Maximilians - University of Munich

  collaborator OTHER

• Azienda USL Reggio Emilia - IRCCS

  collaborator OTHER_GOV

• University of Zurich

  collaborator OTHER

• Centre Hospitalier Universitaire Vaudois

  lead OTHER

Principal Investigators

• Dr. med. Alexander Salerno, MD · CHUV

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2003-01-01

Primary Completion

2023-08-09

Completion

2023-08-09

Countries

• Switzerland

Study Locations