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Association Between Severe-to-profound Hearing Loss and the Balance Function of the Inner Ear

NCT05500521 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 98

Last updated 2026-03-05

No results posted yet for this study

Summary

Severe-to-profound hearing loss can have a major impact on patients´ lives leading to social isolation and decreased quality of life. Most commonly the hearing loss is caused by damage to the inner ear or cochlear nerve. Since the vestibular system which is central for our balance is located in the inner ear it can be suspected that patients with severe-to-profound hearing loss also might have an impaired vestibular function. This impairment may lead to a feeling of dizziness or vertigo. This study aims to investigate if patients with severe-to-profound hearing loss also have impaired vestibular function. The vestibular function will be measured with caloric irrigation, video head impulse test and vestibular evoked myogenic potential.

Conditions

  • Hearing Loss, Sensorineural, Severe
  • Hearing Loss, Sensorineural, Profound
  • Vestibular Disorder

Interventions

DIAGNOSTIC_TEST

Caloric irrigation

In a healthy ear irrigation with warm and cold water should give rise to an intense sensation of vertigo and involuntary eye movements called nystagmus. This nystagmus can be measured and thereby give an indication of the vestibular function in that ear.

DIAGNOSTIC_TEST

vHIT

This test measures the vestibular ocular reflex in all six semicircular canals (three in each ear). By performing a fast head thrust in the direction of the canal the eye response can be detected by a high-velocity video camera. A slower response indicates impaired function in that canal.

DIAGNOSTIC_TEST

VEMP

Utricular and saccular function can be measured by VEMP. Sound is presented in one ear at a time and the evoked myogenic potential in the sternocleidomastoid and the superior oblique muscles can be measured respectively. This gives a measurement of the function of the sacculus (cVEMP) and utriculus (oVEMP).

Sponsors & Collaborators

  • Värmland County Council, Sweden

    lead OTHER_GOV

Principal Investigators

  • Per-Inge Carlsson, PhD · University of Örebro, Faculty of medicine and health

Eligibility

Min Age
50 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-08-30
Primary Completion
2025-06-01
Completion
2025-06-01

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05500521 on ClinicalTrials.gov