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Evaluation of the Global Auditory Nerve Activity for Exploration of Hearing in Humans

NCT03552224 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2021-12-30

No results posted yet for this study

Summary

To date, all the electrophysiological methods for auditory testing rely on the measure on synchronous evoked auditory nerve activity. This measure only takes into account the response of the first action potential in every auditory fibber, but provides no information about the neural response during a sustained activity. This can explain why in experimental models, a loss of more of 80% of auditory nerve fibbers cannot be detected by usual electrophysiological measurements. In this study we aim at investigating the global spontaneous and sound evoked auditory nerve activity by recording directly the electrical field by an electrode placed directly on the auditory nerve of subjects during a skull base surgical procedure. We expected to demonstrated differences in the electrical activity between subjects with or without hearing loss.

Conditions

Interventions

PROCEDURE

Recording of auditory nerve activity

near field recording of auditory nerve activity with contact electrode

Sponsors & Collaborators

  • Institute for Neurosciences of Montpellier U1051

    collaborator UNKNOWN

  • Reims University hospital

    collaborator OTHER

  • University Hospital, Montpellier

    lead OTHER

Principal Investigators

  • Frédéric VENAIL, PU-PH · University Hospital, Montpellier

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-07-11
Primary Completion
2021-06-26
Completion
2021-06-26

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03552224 on ClinicalTrials.gov