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Development of a Battery of Audiological Tests for the Precision Diagnosis of Age-related Hearing Loss

NCT05312983 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 700

Last updated 2025-03-03

No results posted yet for this study

Summary

Age-related hearing loss, or presbycusis, is caused by many genetic and environmental factors. Its prevalence poses a public health challenge of early identification and effective hearing aid treatment. However, the lack of screening and of a validated audiological test battery to diagnose an individual's needs and to guide hearing aid adjustments is a major obstacle.

Furthermore, monogenic forms of hearing loss affect only one functional module of hearing. The audiological test(s) dependent on the function of this module are affected, in a progressive manner, but not the others. A previous study showed that in early onset presbycusis patients, a quarter of the subjects tested were affected by monogenic presbycusis.

The collection of audiological and vestibular tests, carried out on proven monogenic presbycusis patients and compared to that of normal hearing patients, would constitute a battery of tests allowing a precision diagnosis, then developed to all forms of presbycusis in order to study if the identification of abnormal functional modules can usefully guide the diagnosis and the early fitting.

Conditions

  • Presbyacusis

Interventions

OTHER

Audiological and vestibular tests

6h of audiological and vestibular tests divide in 3 sessions : * Session A : objective audiological tests * Session B ; subjective audiological tests * Session C : balance tests.

OTHER

Blood sampling

A 10 mL blood sample will be collected during the study.

OTHER

neurocognitive self-questionnaire

Four self-questionnaires to fill out to measure sleep quality, memory and emotional state

Sponsors & Collaborators

  • CEntre de Recherche et d'Innovation en Audiologie Humaine

    collaborator UNKNOWN

  • Laboratoire de correction auditive

    collaborator UNKNOWN

  • Institut Pasteur

    lead INDUSTRY

Principal Investigators

  • Paul Avan, MD · CERIAH

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-07-28
Primary Completion
2027-12-31
Completion
2030-12-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05312983 on ClinicalTrials.gov