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Association Between Peripheral Muscle Function and Quality of Life in Obese Subjects

NCT05467020 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 84

Last updated 2023-10-11

No results posted yet for this study

Summary

The assessment of health status and physical function is fundamental in patients with obesity, as they play an important role among the various factors influencing the quality of life in this population. Several studies have shown an association between high BMI values and a significant deterioration in quality of life, especially in women. Excess body fat in obese patients seems to be responsible for muscle atrophy. This causal link is probably related to dysfunctions in adipose tissue, leading to a decrease in the expression of proteins responsible for muscle contraction. The recent literature highlights an alteration in quality of life, particularly in obese and elderly subjects, for which changes in muscle function are partly responsible. Changes in muscle function can be assessed by simple, rapid and non-invasive tools. They could be used to identify obese subjects at risk of they could be used to identify obese subjects at risk of muscle atrophy, to stratify the risk, and to propose prophylactic intervention or early management.

The main objective of this study is to evaluate the association between structural alteration of the quadriceps and quality of life in obese patients.

The secondary objectives are to evaluate :

* The association between quadriceps thickness and quality of life ;
* The association between grip strength and quality of life ;
* The association between quadriceps strength and quality of life ;
* The association between quadriceps strength and ultrasound measurements of the quadriceps.

This is a prospective, monocenter, observationnal and cohort study.

All outpatients for nutrition assessment will be included.

Conditions

Sponsors & Collaborators

  • Hopital Forcilles

    lead OTHER

Principal Investigators

  • Sophie VIDAL-JESSEL, MD · Hopital Forcilles

  • Andreia GOMES LOPES, MSc · Hopital Forcilles

  • Aymeric Le Neindre, PhD · Hopital Forcilles

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-22
Primary Completion
2023-07-22
Completion
2023-10-02

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05467020 on ClinicalTrials.gov