Impact of Minimally Invasive and Open Liver Surgery in Different BMI-classes

Summary

Despite the worldwide increase of both obesity and use of minimally invasive liver surgery(MILS), evidence regarding the safety and eventual benefits of MILS in obese patients is scarce. The aim of this study is therefore to compare the outcomes of non-obese and obese patients(BMI 18.5-29.9 and BMI≥30, respectively) undergoing MILS and OLS, and to assess trends in MILS use among obese patients. In this retrospective cohort study, patients operated at 20 hospitals in eight countries(2009-2019) will be included and the characteristics and outcomes of non-obese and obese patients will be compared. Thereafter, the outcomes of MILS and OLS were compared in both groups after propensity-score matching(PSM). Changes in the adoption of MILS during the study period will be investigated.

Conditions

• Liver Cancer
• Liver Metastases
• Obesity

Interventions

PROCEDURE

Minimally invasive liver resection

A liver resection performed by minimally invasive (keyhole) surgery

Sponsors & Collaborators

• Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

  collaborator OTHER

• The Queen Elizabeth Hospital

  collaborator OTHER

• Umberto I Mauriziano Hospital, Turin, Italy

  collaborator UNKNOWN

• Oslo University Hospital and Institute of Medicine, University of Oslo, Oslo, Norway

  collaborator UNKNOWN

• Padua University Hospital, Padua, Italy

  collaborator UNKNOWN

• IRCCS San Raffaele

  collaborator OTHER

• University Hospital of Girona Dr. Josep Trueta

  collaborator NETWORK

• Clinica Universidad de Navarra, Pamplona, Spain

  collaborator UNKNOWN

• Institut Mutualiste Montsouris, Université Paris Descartes, Paris, France

  collaborator UNKNOWN

• Groeninge Hospital, Kortrijk, Belgium

  collaborator UNKNOWN

• University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom

  collaborator UNKNOWN

• Riuniti Hospital, Polytechnic University of Marche, Ancona, Italy

  collaborator UNKNOWN

• University of Verona, Verona, Italy

  collaborator UNKNOWN

• Virginia Mason Medical Center, Seattle, USA

  collaborator UNKNOWN

• University of California San Francisco, California, USA

  collaborator UNKNOWN

• Moscow Clinical Research Centre, Moscow, Russia

  collaborator UNKNOWN

• Università Cattolica del Sacro Cuore-IRCCS, Rome, Italy

  collaborator UNKNOWN

• Antoine Béclère Hospital, Paris, France

  collaborator UNKNOWN

• IRCCS Azienda Ospedaliero-Universitaria di Bologna

  collaborator OTHER

• University of Modena and Reggio Emilia, Modena, Italy

  collaborator UNKNOWN

• Fondazione Poliambulanza Istituto Ospedaliero

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-12-01

Primary Completion

2022-07-18

Completion

2022-07-22

Countries

• Italy

Study Locations