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Early Targeted Antibiotic Therapy in Patients With Sepsis

NCT05459389 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2023-09-28

No results posted yet for this study

Summary

The aim of this study is to assess the efficacy of early targeted antibiotic therapy in patients with sepsis and septic shock using the new biomarker Sirtuin 1 and PCR for bacterial resistance detection.

The primary outcome is change in SOFA score (ΔSOFA) which will be calculated by subtracting the final SOFA score and sirtuin 1 level at 5 days from the corresponding initial value at enrollment.

Secondary outcomes included mortality rates, ventilator free days and length of icu stay.

Conditions

Interventions

OTHER

targeted antibiotics therapy

targeted antibiotics therapy guided by resistance genotyping (n=24)

Sponsors & Collaborators

  • Rehab Werida

    lead OTHER

Principal Investigators

  • Rehab H Werida, Ass. Prof. · Damanhour University

  • Noha Elbassiony · Damanhour University

  • Eman Momtaz · Damanhour University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-05-01
Primary Completion
2023-08-30
Completion
2023-09-01

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05459389 on ClinicalTrials.gov