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VFI in Healthy Vessels

NCT05451485 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2023-05-06

No results posted yet for this study

Summary

There is a wealth of evidence implicating the important role of blood flow throughout all stages of the process of atherogenesis. Two locations along the vascular tree at which atherosclerotic plaques are typically found are the carotid artery (CA) and the superficial femoral artery (SFA). Nowadays, ultrasound is the technique of choice for assessing the vascular condition in the CA and SFA. However, clinically used ultrasound techniques show a large variability in estimating the blood flow velocity, due to multiple limitations. With the advent of ultrafast ultrasound imaging, (almost) all elements of the transducer can be activated simultaneously. These so-called plane wave acquisition acquires thousands of images per second and makes continuous tracking of blood flow velocities in all directions in the field of view possible. This high-frame-rate acquisition opened up new possibilities for blood flow imaging at the CA and SFA, such as blood Speckle Tracking (bST) and ultrasound Particle Image Velocimetry (echoPIV). Both these vector flow imaging (VFI) techniques enable the quantification of 2D blood flow velocity profiles, where bST uses no contrast agents compared to echoPIV. Beside these novel ultrasound based techniques, 4D Phase Contrast Magnetic Resonance Imaging (4D flow MRI) enables a non-invasive quantification of the 4D blood flow velocity profiles (3D + time) and can be used as reference standard for blood flow assessments in-vivo. We therefore aim to evaluate the performance of both VFI techniques in comparison to 4D flow MRI measurements in the CA and SFA of healthy volunteers.

Conditions

  • Carotid Artery Stenosis
  • Superficial Femoral Artery Stenosis

Interventions

DIAGNOSTIC_TEST

Blood speckle tracking

Blood speckle tracking measurements will be acquired of the carotid artery and superficial femoral artery

DIAGNOSTIC_TEST

Ultrasound particle Imaging Velocimetry

Ultrasound particle imaging velocimetry will be acquired of the carotid artery and superficial femoral artery

DIAGNOSTIC_TEST

4D flow MRI

4D flow MRI will be acquired of the carotid artery and superficial femoral artery

DIAGNOSTIC_TEST

Conventional duplex

Conventional duplex measurements will be acquired of the carotid artery and superficial femoral artery

Sponsors & Collaborators

  • Rijnstate Hospital

    lead OTHER

Principal Investigators

  • Michel Reijnen, MD, Prof · Rijnstate Hospital

Eligibility

Min Age
20 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-11-05
Primary Completion
2023-03-18
Completion
2023-03-18

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05451485 on ClinicalTrials.gov