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Hybrid Ablation of Atrial Fibrillation in Heart Failure

NCT05411614 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2025-11-28

No results posted yet for this study

Summary

A randomised controlled trial to assess the efficacy of staged hybrid ablation when compared with standard catheter ablation in patients with non-paroxysmal atrial fibrillation (AF) and Heart Failure

Conditions

Interventions

DEVICE

AtriCure EPi-Sense-AF Guided Coagulation System +/- Atriclip

Minimally-invasive epicardial ablation +/- left atrial appendage exclusion using an epicardial clip, combined with endocardial radiofrequency catheter ablation

DEVICE

Endocardial Catheter Ablation

Standard percutaneous endocardial catheter ablation of atrial fibrillation

Sponsors & Collaborators

  • St. George's Hospital, London

    lead OTHER

Principal Investigators

  • Riyaz A Kaba · St Georges Hospital NHS Trust

  • Omar Ahmed · St Georges Hospital NHS Trust

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-25
Primary Completion
2026-05-31
Completion
2027-10-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05411614 on ClinicalTrials.gov