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Temporal Immunologic Changes With Hypofractionated Radiation-Induced DNA Damage in Breast Cancer

NCT05406232 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 36

Last updated 2026-05-06

No results posted yet for this study

Summary

This study assesses changes to the immune cells following hypofractionated radiation-induced DNA damage in breast cancer patients. Radiation therapy may cause immune cells to enter tumors and target cancer cells. The goal of this study is to measure the change in the level of immune cells in the tumor before and after radiation therapy.

Conditions

  • Breast Carcinoma
  • Invasive Breast Carcinoma

Interventions

PROCEDURE

Biopsy

Undergo tumor punch biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

RADIATION

Radiation Therapy

Undergo RT

Sponsors & Collaborators

  • Artidis

    collaborator INDUSTRY

  • M.D. Anderson Cancer Center

    lead OTHER

Principal Investigators

  • Simona F Shaitelman, MD · M.D. Anderson Cancer Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-15
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05406232 on ClinicalTrials.gov