Translating Genetic Knowledge Into Clinical Care in Non-Autoimmune Diabetes

Summary

The aim of TRANSLATE is to implement genetic information directly into patient care to improve diagnosis and treatment of non-autoimmune diabetes. This project is the first large-scale implementation of systematic genetic testing within a common, non-communicable, chronic disease in Denmark, and will spearhead efforts to advance personalized medicine in Denmark.

The project will contribute to establishing technology, workflow, and evidence on how to implement and communicate actionable genetic information to clinicians and patients in a generalized format. These developments are pivotal for personalized medicine to reach broader clinical application.

Conditions

• Diabetes Mellitus, Type 2
• Diabetes, Gestational

Interventions

OTHER

Whole genome sequencing

Each participant will have WGS performed in order to report on clinically actionable genetic variation in diabetes.

Sponsors & Collaborators

• Steno Diabetes Center Copenhagen

  collaborator OTHER

• BGI Europe

  collaborator UNKNOWN

• Intomics A/S

  collaborator UNKNOWN

• Rigshospitalet, Denmark

  collaborator OTHER

• Danish National Genome Center

  collaborator UNKNOWN

• Nordsjaellands Hospital

  collaborator OTHER

• Herlev Hospital

  collaborator OTHER

• Hvidovre University Hospital

  collaborator OTHER

• University of Copenhagen

  lead OTHER

Principal Investigators

• Torben Hansen, PhD · University of Copenhagen

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-05-06

Primary Completion

2025-05-31

Completion

2027-05-31

Countries

• Denmark

Study Locations