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Genetic Physiopathology and Evolution of Type 2 Diabetes

NCT00879801 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1017

Last updated 2009-04-10

No results posted yet for this study

Summary

There are few longitudinal studies in the Caucasian population and even less in the Italian population in subjects with impaired glucose regulation to allow:

1. An estimate of the rate of conversion to type 2 diabetes;
2. To identify subjects at risk; and
3. To assess the physiopathologic mechanisms responsible for the conversion.

In order to set up a longitudinal study capable of defining the above parameters it is mandatory that the physiological, biochemical, and, genetic markers specific for IGR are identified. The goals of the present research proposal are:

1. To clarify the physiological mechanisms responsible for IGR;
2. To identify the biochemical and beta-cell auto-immune parameters present in IGR;
3. Identify genetic markers.

The subjects who will be identified will add up to other 900 individuals who will be recruited as part of a follow-up program sponsored by the Italian Society of Diabetes, specifically designed to assess conversion rate to diabetes.

Conditions

  • Pre-Diabetes

Sponsors & Collaborators

  • Italian Society of Diabetology

    collaborator OTHER

  • Eli Lilly and Company

    collaborator INDUSTRY

  • University of Pisa

    lead OTHER

Eligibility

Min Age
30 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2003-01-31
Primary Completion
2008-12-31
Completion
2008-12-31

Countries

  • Italy

Study Locations

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Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00879801 on ClinicalTrials.gov