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Myocardial Injury and Severe Pneumococcal Pneumonia

NCT03058211 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 23

Last updated 2021-07-01

No results posted yet for this study

Summary

Hypothesis: The "novo" cardiovascular events (CVE)in patients with severe community-acquired pneumonia (CAP) are frequent (17%) and could be associated with both direct pneumococcal myocardial invasion, toxin delivery (pneumolysin) or different biomarkers (histones, NETs(neutrophil extracellular traps), IL (Interleukin)-1b,h-Fabp (heart-Fatty acid bindding protein) ).The CVE frequency and its impact on outcome in patients without prior heart disease (CP) has not been studied.

Objectives:1) To determine the incidence of myocardian injury (MI) and CVE in patients with CAP without CP evaluated by non-invasive techniques (Echocardiograph and MRI) and biomarkers levels (Tn-I (Troponin I), h-Fabp, NT-proBNP (N-terminal pro-brain natriuretic peptide) histones, NETs, IL 1b); 2) To assess if DMA and CVE are related to the etiology and their impact on outcome , 3) To investigate the presence of myocardial scarring by MRI and its relationship with etiology and MI, and 4) To identify prognostic factors of DMA and CVE to determine level of risk.

Conditions

  • Pneumonia, Pneumococcal
  • Myocardial Ischemia

Interventions

DIAGNOSTIC_TEST

Echocardiography

Standard protocols

DIAGNOSTIC_TEST

Cardiac Magnetic resonance

MRI with late gadolinium increase and T1 mapping

Sponsors & Collaborators

  • Alejandro Rodriguez Oviedo , MD

    lead OTHER

Principal Investigators

  • Alejandro H Rodriguez Oviedo · Hospital Universitari de Tarragona Joan XXIII

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-03-01
Primary Completion
2019-05-31
Completion
2019-12-31

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03058211 on ClinicalTrials.gov