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Multicenter Comparison of Interictal HFO as a Predictor of Seizure Freedom

NCT05332990 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2023-12-07

No results posted yet for this study

Summary

In drug-resistant focal epilepsy, interictal high frequency oscillations (HFO) recorded from intracranial EEG (iEEG) may provide clinical information for delineating epileptogenic brain tissue. The iEEG electrode contacts that contain HFO are hypothesized to delineate the epileptogenic zone; their resection should then lead to postsurgical seizure freedom.

We test whether our prospective definition of clinically relevant HFO is in agreement with postsurgical seizure outcome. The algorithm is fully automated and is equally applied to all datasets. The aim is to assess the reliability of the proposed detector and analysis approach.

Conditions

  • Epilepsy Intractable

Interventions

DIAGNOSTIC_TEST

HFO analysis

We use an automated data-independent prospective definition of clinically relevant HFO that has been validated in data from two independent epilepsy centers.

Sponsors & Collaborators

  • McGill University

    collaborator OTHER

  • University of Michigan

    collaborator OTHER

  • University of Calgary

    collaborator OTHER

  • Cook Children's Health Care System

    collaborator OTHER

  • St. Anne's University Hospital Brno, Czech Republic

    collaborator OTHER

  • Mayo Clinic

    collaborator OTHER

  • Thomas Jefferson University

    collaborator OTHER

  • UMC Utrecht

    collaborator OTHER

  • Schweizerisches Epilepsie Zentrum

    collaborator UNKNOWN

  • University of Zurich

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-05-01
Primary Completion
2024-05-01
Completion
2024-05-01

Countries

  • Switzerland

Study Locations

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Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05332990 on ClinicalTrials.gov