PET/MRI/EEG Imaging Study in Epilepsy
NCT06974305 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 30
Last updated 2026-04-23
Summary
This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.
Conditions
Interventions
- RADIATION
-
FDG-PET/fMRI/EEG imaging
Subject will undergo simultaneous EEG, fMRI, and FDG-PET imaging. This includes the use of a standard injected radioactive marker used in PET imaging.
Sponsors & Collaborators
-
Massachusetts General Hospital
lead OTHER
Principal Investigators
-
Ciprian Catana, MD, PhD · Massachusetts General Hospital
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2023-09-21
- Primary Completion
- 2026-12-31
- Completion
- 2026-12-31
Countries
- United States
Study Locations
More Related Trials
-
Electroencephalography (EEG) and Deep Brain Stimulation (DBS) in Epilepsy
NCT00194870 ·Status: COMPLETED ·Phase: NA
-
Localizing the Epileptogenic Zone With High Resolution Electroencephalography
NCT01090934 ·Status: COMPLETED ·Phase: NA
-
Non-Invasive Seizure Localization in Patients With Medically Refractory Localization Related Epilepsy: Synchronized MEG-EEG Recordings
NCT00071305 ·Status: COMPLETED
-
Electrophysiologic Studies of Cognition in Epilepsy Patients
NCT05769634 ·Status: COMPLETED ·Phase: NA
-
Electrical Impedance Tomography of Epilepsy
NCT03050931 ·Status: ACTIVE_NOT_RECRUITING
-
Study on Neurocognitive Plasticity in Patients With Focal and Drug-resistant Epilepsy
NCT03543267 ·Status: COMPLETED ·Phase: NA
-
Simultaneous MEG or fMRI And INtracranial EEG
NCT02342938 ·Status: COMPLETED ·Phase: NA
-
" Virtual Brain "-Based Interpretation of Electrophysiological Signals in Epilepsy
NCT02603640 ·Status: COMPLETED ·Phase: NA
-
Concomitant High-resolution Recording of Haemodynamic and Electrical Activities of Children With Typical or Atypical Absence Seizures
NCT02819427 ·Status: UNKNOWN
-
SEEG Investigation of Mood Dysregulation in Epilepsy
NCT03097809 ·Status: COMPLETED
-
Usefulness of Sodium MRI in the Presurgical Assessment of Drug-resistant Partial Epilepsy
NCT02304029 ·Status: COMPLETED ·Phase: NA
-
Study of Direct Brain Recording and Stimulation for Memory Enhancement
NCT04095026 ·Status: ENROLLING_BY_INVITATION
-
Exploring the Characteristics of Epileptogenic Foci in Drug-Resistant Epilepsy Based on Multimodal Imaging Technology
NCT06557720 ·Status: RECRUITING
-
National Study on the Interest of EEG-fMRI in the Presurgical Evaluation of Partial Epilepsies Drug
NCT03278210 ·Status: COMPLETED
-
Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy
NCT03946618 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
MEG Versus EEG HR for the Localization of the Epileptogenic Zone as Part of the Pre-surgical Assessment of Epilepsy
NCT03893916 ·Status: RECRUITING ·Phase: NA
-
Impact of Epileptic Discharge on the Structural Connectivity of the Developing Brain
NCT03268824 ·Status: RECRUITING
-
Monitoring Patients With Uncontrolled Epilepsy
NCT00001149 ·Status: COMPLETED
-
Localizing Epileptic Networks Using MRI and iEEG
NCT04649008 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Multi-scale Analysis of Physiological Brain Networks
NCT03912155 ·Status: RECRUITING
-
Functional Brain Mapping for Patients with Epilepsy
NCT05755919 ·Status: RECRUITING ·Phase: NA
-
Spectral Dynamic Imaging of Cognitive Functions in Epileptic Patients Explored Stereoelectroencephalography
NCT02869698 ·Status: COMPLETED ·Phase: NA
-
Neurofeedback-enhanced Mindfulness Meditation in Traumatic Brain Injury
NCT02615535 ·Status: COMPLETED ·Phase: NA
-
Quantitative EEG Markers in Mild Cognitive Impairment in Epilepsy
NCT04376671 ·Status: COMPLETED
-
Epilepsy Seizure Detection With Innovative Tripolar EEG (tEEG)
NCT05944692 ·Status: RECRUITING