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Promote Brain Resilience for the Coronavirus (COVID-19) Pandemic

NCT05293431 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2023-06-23

No results posted yet for this study

Summary

Background:

By the end of 2020, the coronavirus disease (COVID-19) pandemic resulted in over 84 million cases and nearly 2 million deaths.

Continued confinement and restriction are expected to negatively affect mental health, however, some individuals are likely to show much less negative impact than others. The characterization and neurobiological determinants of brain resilience vs vulnerability during the pandemic should generate critical knowledge and open future avenues for individually tailored interventions.

Objectives:

1. Identify the individual psychobiological determinants of resilience during COVID-19 pandemic.
2. Conduct a non-invasive brain stimulation intervention to modulate the expression of resilience brain networks.

Methods:

Barcelona Brain Health Initiative participants will be included, encompassing multiple assessments before and during the COVID-19 pandemic. Machine learning techniques will be applied to define brain networks signature of resilience. Subsequently transcranial alternating stimulation will be used during a controlled trial intervention to promote the expression of brain resilience networks.

Expected results:

The present project should provide critical new knowledge on brain mechanisms underlying resilience and first evidences of the feasibility and impact of modulating brain resilience networks in terms of its effects on mental health of participants.

Conditions

  • Transcranial Direct Current Stimulation
  • Mental Health Issue
  • Public Health
  • Resilience, Psychological
  • COVID-19

Interventions

OTHER

Transcranial Alternate Current Stimulation

tACS utilizes low-amplitude alternating currents to modulate brain activity and entrain specific brain oscillations depending on the applied stimulation frequency

OTHER

Sham stimulation

Sham stimulation will simulated the real tACS stimulation

Sponsors & Collaborators

  • University of Barcelona

    collaborator OTHER

  • Institut Guttmann

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-09-01
Primary Completion
2023-07-31
Completion
2023-11-15

Countries

  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05293431 on ClinicalTrials.gov