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Developing Advanced Neuroimaging for Clinical Evaluation of Autoimmune Encephalitis

NCT05280600 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 75

Last updated 2023-10-06

No results posted yet for this study

Summary

Autoimmune encephalitis is brain inflammation caused by the immune system mistakenly reacting against proteins in the brain. The commonest form is called NMDAR-antibody encephalitis (N-methyl-D-aspartate receptor antibody encephalitis), a rare condition which mainly affects children and young people and causes difficulties in memory, thinking and mental health which can have significant long-term impacts on education, employment and quality of life.

In this project we will use advanced magnetic resonance imaging (MRI) to measure changes in the structure, function and chemistry of the brains of children and young people who are in early recovery from NMDAR-antibody encephalitis and other forms of immune-mediated encephalitis. We will investigate if MRI measurements in patients differ from those in healthy people, and if they can help predict patient outcome one year later, assessed by tests of memory, thinking, mental health and functioning in daily life.

Conditions

  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis
  • Autoimmune Encephalitis

Interventions

OTHER

Not applicable - non-interventional study

Not applicable - non-interventional study

Sponsors & Collaborators

  • Guy's and St Thomas' NHS Foundation Trust

    collaborator OTHER

  • Action Medical Research

    collaborator OTHER

  • King's College London

    lead OTHER

Principal Investigators

  • David W Carmichael, PhD MSci · King's College London

Eligibility

Min Age
8 Years
Max Age
24 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-05-19
Primary Completion
2024-02-28
Completion
2026-02-28

Countries

  • United Kingdom

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05280600 on ClinicalTrials.gov