Meningitis Encephalitis: a Metagenomics-Based Etiology & Epidemiology Research

Summary

Autoimmune encephalitis (AE) is caused by abnormal immune response mediated by autoimmune antibodies of patients, which can be detected by a serial of autoimmune antibodies\[4,5,6,7\]. At present, the traditional infection diagnosis mainly relies on microbial culture method, which has the characteristics of long cycle, high cost, low detection rate and complex detection process. About 30-60% of encephalitis have unknown etiology\[2,3\]. On the other hand, the diagnosis and classification of noninfectious encephalitis mainly depend on the detection of autoimmune antibodies, the scope of diagnosis and differential diagnosis is limited, and the relationship between autoimmune encephalitis and infection factors is still unclear. Metagenomics sequencing (mNGS) is a new method that does not rely on microbial culture and can directly detect pathogenic nucleic acids. It has the characteristics of fast, accurate, high throughput, no preference for different pathogen detection, and can detect known and unknown pathogens at the same time. Nowadays, mNGS is widely used in the field of pathogen detection.

Conditions

• Central Nervous System Infections and Inflammations

Sponsors & Collaborators

• Beijing Tiantan Hospital

  collaborator OTHER

• Air Force Military Medical University, China

  collaborator OTHER

• Peking Union Medical College Hospital

  collaborator OTHER

• The Second Hospital of Hebei Medical University

  collaborator OTHER

• First Affiliated Hospital, Sun Yat-Sen University

  collaborator OTHER

• Chinese PLA General Hospital

  collaborator OTHER

• Xuanwu Hospital, Beijing

  collaborator OTHER

• Third Affiliated Hospital, Sun Yat-Sen University

  collaborator OTHER

• Shandong Provincial Hospital

  collaborator OTHER_GOV

• Fudan University

  collaborator OTHER

• West China Hospital

  collaborator OTHER

• Henan Provincial People's Hospital

  collaborator OTHER

• Central South University

  collaborator OTHER

• The First Affiliated Hospital of Shanxi Medical University

  collaborator OTHER

• Beijing Tongren Hospital

  lead OTHER

Principal Investigators

• Jiawei Wang, Doctor · Beijing Tong Ren Hospital

Eligibility

Min Age

14 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-12-31

Primary Completion

2023-06-30

Completion

2023-06-30

Countries

• China

Study Locations